Biological Information
Family:
Ion Channel
Sub Family:
Potassium
Class:
Voltage-Gated
Protein Name:
SKCa
Uniprot Number:
Q92952(human)
Gene Name:
KCNN1
Gene ID:
3780
Organism:
Rat
Tissue:
Brain
Assay Information
Assay Type:
Biochemical
Assay Sub Type:
Binding
Detection Method:
Radiometric
Measured Response:
Scintillation
Testing Information
Ligand:
[125I]apamin
Ligand Kd (nM):
0.007
Ligand Concentration:
0.007 nM
Non Specific:
100 nM Apamin
Incubation:
60 min at 4°C
Control Inhibitor:
Apamine
Test Concentration / Dose:
Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.
Test Sample Requirements:
Minimum for 1) Screen: 60 µl of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM final testing. 2) Dose Response: 90 µl of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
2
Turnaround Time
Standard:
10 Business Days
Reference Compound Data
Clinical Relevance
Therapeutic Area:
CNS/Addiction/Pain
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
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