Biological Information

Family:

Ion Channel

Sub Family:

Potassium

Class:

Voltage-Gated

Protein Name:

SKCa

Uniprot Number:

Q92952(human)

Gene Name:

KCNN1

Gene ID:

3780

Organism:

Rat

Tissue:

Brain

Assay Information

Assay Type:

Biochemical

Assay Sub Type:

Binding

Detection Method:

Radiometric

Measured Response:

Scintillation

Testing Information

Ligand:

[125I]apamin

Ligand Kd (nM):

0.007

Ligand Concentration:

0.007 nM

Non Specific:

100 nM Apamin

Incubation:

60 min at 4°C

Control Inhibitor:

Apamine

Test Concentration / Dose:

Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.

Test Sample Requirements:

Minimum for 1) Screen: 60 µl of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM final testing. 2) Dose Response: 90 µl of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.

Minimum Order Quantity:

2

Turnaround Time

Standard:

10 Business Days

Reference Compound Data

PubChem ID

57654199

Name

Glibenclamide

Measurement

- IC50

PubChem ID

24890526

Name

Apamine

Measurement

0.021nM - IC50

PubChem ID

154585695

Name

Alpha dendrotoxin

Measurement

- IC50

Clinical Relevance

Therapeutic Area:

CNS/Addiction/Pain

Additional Information

Brand:

LeadHunter

Testing Location:

France - Celle L'Evescault

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