SERT Human Serotonin Transporter Binding Antagonist Radioligand LeadHunter Assay - FR

Background Information:

The actions of several neurotransmitters, including serotonin, are regulated through their rapid uptake and clearance from synaptic junctions by plasma membrane transport proteins. The serotonin transporter in central serotoninergic neurons is responsible for the recovery of up to 90 percent of released transmitter. The monoamine transporters are high affinity targets for a number of psychoactive agents such as cocaine, amphetamine, and antidepressants. These agents, by blocking transporters and consequently preventing neuronal uptake, elevate levels of extracellular neurotransmitter concentration in both the central and peripheral nervous systems, contributing to their behavioral and autonomic effects.

Family:

Transporter

Sub Family:

SLC6 / Monoamine

Class:

SLC

Protein Name:

SERT

Uniprot Number:

P31645

Protein Aliases:

serotonin transporter 1

Gene Name:

SLC6A4

Gene ID:

6532

Gene Aliases:

5-HTT|SERT1|HTT

Accession Number:

NM_001045

Organism:

Human

Construct Details:

Recombinant