MT1 Human Melatonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR

Background Information:

Melatonin receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Melatonin, present primarily in the central nervous system, is released following a circadian rhythm with high levels at night.

Family:

GPCR

Sub Family:

Melatonin

Class:

Class A

Protein Name:

MT1

Uniprot Number:

P48039

Protein Aliases:

Mel1a receptor

Gene Name:

MTNR1A

Gene ID:

4543

Gene Aliases:

MEL-1A-R

Accession Number:

XM_011532002

Organism:

Human

Construct Details:

Recombinant