OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Why choose SafetyScreen18:
The SafetyScreen18 Functional Core Panel provides IC₅₀/EC₅₀ dose–response data across 18 high-priority targets strongly associated with clinical adverse effects, enabling very early de-risking.
The panel design is informed by current industry best practices reflecting meta-analysis of Top 20 pharma worldwide under the IQ DruSafe consortium (Brennan, R.J., et al. Nat Rev Drug Discov , 2024) to support safety margin calculations, allowing an anticipated and context-driven safety assessment
Key specs:
Testing conditions: Dose Response
Total assays: 26
Includes: P452-EU (23 assays) + P452-US (3 assays)
Checkout: Add P452-EU to your cart and P452-US is automatically added so your quote includes the full 26 assays covering 18 targets.
Kinases tested at 1mM ATP condition for more physiological relevance.
Where to find details:
See DOCUMENTS/REFERENCES (above) for the full assay list to be downloaded.
For P452-US assay details only, see RELATED SOLUTIONS (below).
Key Benefits
Cost-effective: package
Coming Soon! Visualization and interpretation tool, In Vitro Safety Insight transform your screening data into contextualized safety insights by visualizing organ risks based on target activity, clinical exposure, and customizable safety margins for a more risk informed assessment (available in your online account).
Access data early: results released as they are validated.
Final report delivered electronically with notification.
What’s next:
In order to get a complete safety assessment and for IND-submission, SatetyScreen59 (P458) needs to be performed in cascade after SafetyScreen18 to reach the 77 latest recommended targets by the industry.
No. of Assays on Panel:
23
Assays on Panel:
Family
GPCR
Name
M3 Human Acetylcholine (Muscarinic) GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
1243
Protein
M3
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
M3 Human Acetylcholine (Muscarinic) GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
1244
Protein
M3
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
mu (MOP) Human Opioid GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
1392
Protein
mu (MOP)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
mu (MOP) Human Opioid GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
1393
Protein
mu (MOP)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
alpha1A Human Adrenoceptor GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
1500
Protein
alpha1A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
alpha1A Human Adrenoceptor GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
1501
Protein
alpha1A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
D1 Human Dopamine GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
1685
Protein
D1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
D1 Human Dopamine GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
1686
Protein
D1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CB1 Human Cannabinoid GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
1744
Protein
CB1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CB1 Human Cannabinoid GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
1745
Protein
CB1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
beta2 Human Adrenoceptor GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
1976
Protein
beta2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
beta2 Human Adrenoceptor GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
1977
Protein
beta2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
H1 Human Histamine GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
2542
Protein
H1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
H1 Human Histamine GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
2543
Protein
H1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT2B Human Serotonin GPCR Cell Based Agonist IP1 LeadHunter Assay - FR
Item
3344
Protein
5-HT2B
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT2B Human Serotonin GPCR Cell Based Antagonist IP1 LeadHunter Assay - FR
Item
3345
Protein
5-HT2B
Organism
Human
Assay Sub Type
Cell Based
Family
Enzyme
Name
Acetylcholinesterase Human Enzymatic LeadHunter Assay - FR
Item
363
Protein
AChE
Organism
Human
Assay Sub Type
Enzymatic
Family
Enzyme
Name
PDE3A Human Phosphodiesterase Enzymatic LeadHunter Assay - FR
Item
4072
Protein
PDE3A
Organism
Human
Assay Sub Type
Enzymatic
Family
Enzyme
Name
PDE4D2 Human Phosphodiesterase Enzymatic LeadHunter Assay - FR
Item
4077
Protein
PDE4D
Organism
Human
Assay Sub Type
Enzymatic
Family
Transporter
Name
NET Human Norepinephrine Transporter Functional Antagonist Uptake LeadHunter Assay - FR
Item
4661
Protein
NET
Organism
Human
Assay Sub Type
Cell Based
Family
Transporter
Name
DAT Human Dopamine Transporter Functional Antagonist Uptake LeadHunter Assay - FR
Item
4865
Protein
DAT
Organism
Human
Assay Sub Type
Cell Based
Family
Kinase
Name
Lck Human TK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5911
Protein
Lck
Organism
Human
Assay Sub Type
Enzymatic
Family
Ion Channel
Name
hERG (KV11.1) Human Potassium Ion channel Cell Based Antagonist LeadHunter Assay - FR
Item
5921
Protein
KV11.1
Organism
Human
Assay Sub Type
Cell Based
Testing Information
Test Sample Requirements:
490 µL of a 333× DMSO stock solution, calculated from the top concentration to be tested (PBS working solutions are not compatible)
Turnaround Time
Standard:
20 Business Days
Service Scheduling Note:
Fixed monthly study start dates
See DOCUMENTS/REFERENCES (above) for compound receipt deadlines, study start dates, results delivery dates, and final report dates.
Compounds must be received by the stated deadline to be included in a given session
(late receipts are automatically scheduled for the next available session)
Results published online in your personal account on a rolling basis as tests are validated
Final reports delivered electronically, with email notification upon posting.
Additional Information
Brand:
SafetyScreen
Testing Location:
France - Celle L'Evescault
Other Information:
Available on demand in single-concentration screening format. Contact us for more information : ClientServicesPoitiers@discovery.eurofinseu.com
Please see Related Solutions below for more panels formats.
RELATED SOLUTIONS
CiPA hNav1.5 Sodium Channel Assay - Qube APC (6 Conc.) SafetyScreen - US
Item: CYL8004QB2DR
CiPA hCav1.2 (L-type) Calcium Channel Assay - Qube APC (6 Conc.) SafetyScreen - US
Item: CYL7051QB2DR
SafetyScreen18 Core Panel - FR
Item: P447
SafetyScreen59 Extended Panel - FR
Item: P448
SafetyScreen77 Core Extended Panel - FR
Item: P456
SafetyScreen59 Functional Extended Panel - FR
Item: P458-EU
SafetyScreen77 Functional Core Extended Panel - FR
Item: P460-EU
Questions? Contact Us
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