OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Why choose SafetyScreen59:
The SafetyScreen59 Functional Extended Panel provides IC₅₀/EC₅₀ -based safety profiling across 59 recommended targets , including 33 emerging ones, with strong representation of GPCRs and kinases, enabling early de-risking and broader detection of potential safety liabilities. It provides follow-up screening after the initial SafetyScreen18 Panel, in order to reach the 77-target safety coverage considered current industry best practices for early off-target risk assessment, as reflected in meta-analysis of Top 20 pharma worldwide under the IQ DruSafe consortium (Brennan et al., Nat Rev Drug Discov , 2024).
The resulting data support safety-margin calculations and earlier risk detection to help advance safer drug candidates.
Key specs:
Testing conditions: Dose Response
Kinases tested at 1mM ATP condition for more physiological relevance.
The combination of SafetyScreen18 and SafetyScreen59 is ICH S7A/B aligned for IND-submission.
Key Benefits
Cost-effective package
Coming Soon! Visualization and interpretation tool, In Vitro Safety Insight transform your screening data into contextualized safety insights by visualizing organ risks based on target activity, clinical exposure, and customizable safety margins for a more risk informed assessment (available in your online account).
Access data early: results released as they are validated.
Final report delivered electronically with notification.
No. of Assays on Panel:
85
Assays on Panel:
Family
GPCR
Name
V1A Human Vasopressin / Oxytocin GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
1033
Protein
V1A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
V1A Human Vasopressin / Oxytocin GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
1034
Protein
V1A
Organism
Human
Assay Sub Type
Cell Based
Family
Lipid Metabolism
Name
COX1 Human Cyclooxygenase Enzymatic LeadHunter Assay - TW
Item
116030
Protein
COX1
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
M1 Human Acetylcholine (Muscarinic) GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
1262
Protein
M1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
ETA Human Endothelin GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
1264
Protein
ETA
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
NK3 Human Tachykinin GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
1312
Protein
NK3
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
M1 Human Acetylcholine (Muscarinic) GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
1474
Protein
M1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
beta1 Human Adrenoceptor GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
1605
Protein
beta1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
beta1 Human Adrenoceptor GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
1606
Protein
beta1
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT6 Human Serotonin GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
1627
Protein
5-HT6
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT6 Human Serotonin GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
1628
Protein
5-HT6
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
M2 Human Acetylcholine (Muscarinic) GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
1658
Protein
M2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
M2 Human Acetylcholine (Muscarinic) GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
1659
Protein
M2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
H2 Human Histamine GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
1695
Protein
H2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
H2 Human Histamine GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
1696
Protein
H2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CB2 Human Cannabinoid GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
1746
Protein
CB2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CB2 Human Cannabinoid GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
1747
Protein
CB2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
NK3 Human Tachykinin GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
1766
Protein
NK3
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CCK1 (CCKA) Human Cholecystokinin GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
1876
Protein
CCK1 (CCKA)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CCK1 (CCKA) Human Cholecystokinin GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
1877
Protein
CCK1 (CCKA)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CCK2 (CCKB) Human Cholecystokinin GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
1878
Protein
CCK2 (CCKB)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
CCK2 (CCKB) Human Cholecystokinin GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
1879
Protein
CCK2 (CCKB)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
A2A Rat Adenosine GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
2055
Protein
A2A
Organism
Rat
Assay Sub Type
Cell Based
Family
GPCR
Name
A2A Rat Adenosine GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
2056
Protein
A2A
Organism
Rat
Assay Sub Type
Cell Based
Family
NHR
Name
RARalpha Human Retinoic Acid NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
2084
Protein
RARalpha
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
ETA Human Endothelin GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
2257
Protein
ETA
Organism
Human
Assay Sub Type
Cell Based
Family
NHR
Name
PR Human Progesterone NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
2341
Protein
PR
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2A Human Serotonin GPCR Cell Based Agonist IP1 LeadHunter Assay - FR
Item
3196
Protein
5-HT2A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT2A Human Serotonin GPCR Cell Based Antagonist IP1 LeadHunter Assay - FR
Item
3198
Protein
5-HT2A
Organism
Human
Assay Sub Type
Cell Based
Family
Enzyme
Name
Monoamine Oxidase B (MAO-B) Human Enzymatic LeadHunter Assay - FR
Item
3477
Protein
MAO-B
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
GPBA (TGR5) Human Bile Acid GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
3998
Protein
TGR5
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
GPBA (TGR5) Human Bile Acid GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
4093
Protein
TGR5
Organism
Human
Assay Sub Type
Cell Based
Family
Enzyme
Name
COX2 Human Cyclooxygenase Enzymatic LeadHunter Assay - FR
Item
4186
Protein
COX2
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
D2L Human Dopamine GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
4253
Protein
D2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
D2L Human Dopamine GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
4254
Protein
D2
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
MRGX2 (MRGPRX2) Human Class A Orphan GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
4282
Protein
MRGX2 (MRGPRX2)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
MRGX2 (MRGPRX2) Human Class A Orphan GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
4283
Protein
MRGX2 (MRGPRX2)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
alpha2A Human Adrenoceptor GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
4316
Protein
alpha2A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
alpha2A Human Adrenoceptor GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
4317
Protein
alpha2A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
delta (DOP) Human Opioid GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
4328
Protein
delta (DOP)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
delta (DOP) Human Opioid GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
4329
Protein
delta (DOP)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT1A Human Serotonin GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
4332
Protein
5-HT1A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT1A Human Serotonin GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
4333
Protein
5-HT1A
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT1B Human Serotonin GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
4385
Protein
5-HT1B
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT1B Human Serotonin GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
4386
Protein
5-HT1B
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
kappa (KOP) Human Opioid GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
4459
Protein
kappa (KOP)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
kappa (KOP) Human Opioid GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
4460
Protein
kappa (KOP)
Organism
Human
Assay Sub Type
Cell Based
Family
Transporter
Name
SERT Human Serotonin Transporter Functional Antagonist Uptake LeadHunter Assay - FR
Item
4864
Protein
SERT
Organism
Human
Assay Sub Type
Cell Based
Family
Enzyme
Name
Monoamine Oxidase A (MAO-A) Human Enzymatic LeadHunter Assay - FR
Item
5108
Protein
MAO-A
Organism
Human
Assay Sub Type
Enzymatic
Family
Epigenetic
Name
BRD4 (1) Human Bromodomain-Containing 4 Binding LeadHunter Assay - FR
Item
5716
Protein
BRD4
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
MALT1 Human Protease Enzymatic Fluorimetry LeadHunter Assay - FR
Item
5717
Protein
MALT1
Organism
Human
Assay Sub Type
Enzymatic
Family
Ion Channel
Name
5-HT3a Human Serotonin Ion Channel Functional Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
5742
Protein
5-HT3A
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
5-HT3a Human Serotonin Ion Channel Functional Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
5746
Protein
5-HT3A
Organism
Human
Assay Sub Type
Cell Based
Family
NHR
Name
ERalpha Human Estrogen NHR Cell Based Agonist Reporter LeadHunter Assay - FR
Item
5747
Protein
ERalpha
Organism
Human
Assay Sub Type
Cell Based
Family
NHR
Name
GR Human Glucocorticoid NHR Cell Based Agonist Reporter LeadHunter Assay - FR
Item
5748
Protein
GR
Organism
Human
Assay Sub Type
Cell Based
Family
Transporter
Name
GAT1 Human GABA Transporter Functional Antagonist Uptake LeadHunter Assay - FR
Item
5774
Protein
GAT-1
Organism
Human
Assay Sub Type
Cell Based
Family
Kinase
Name
MKK7 (MAP2K7) Human Kinase STE Enzymatic [Km ATP] SafetyScreen - FR
Item
5814
Protein
MAPKK 7
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
ATM Human PIKK Kinase Enzymatic [1mM ATP] SafetyScreen - FR
Item
5891
Protein
ATM
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Aurora-A (AURKA) Human Other Protein Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5892
Protein
Aurora-A
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Aurora-B (AURKB) Human Other Protein Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5893
Protein
Aurora-B
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
c-Kit Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5894
Protein
Kit
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
CLIK (STK35) Human Other Protein Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5895
Protein
CLIK
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
EGFR Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5896
Protein
EGFR
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
FAK Human TK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5897
Protein
FAK
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
TRKA Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5898
Protein
TRKA
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
FGFR1 Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5899
Protein
FGFR1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Src Human TK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5900
Protein
Src
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
ROCK2 Human AGC Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5901
Protein
ROCK2
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
ROCK1 Human AGC Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5902
Protein
ROCK1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Flt-1 (VEGFR1) (FLT1) Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5903
Protein
Flt-1 (VEGFR1)
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
GSK3beta (GSK3B) Human CMGC Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5905
Protein
GSK3beta
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
KDR (VEGFR2) (KDR) Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5906
Protein
KDR (VEGFR2)
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
IR (INSR) Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5907
Protein
IR
Organism
Human
Assay Sub Type
Enzymatic
Family
Ion Channel
Name
Glutamate (NMDA, NR1/NR2A) Human Ion Channel Cell Based Agonist LeadHunter Assay - FR
Item
5916
Protein
GluN2A
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
Glutamate (NMDA, NR1/NR2A) Human Ion Channel Cell Based Antagonist LeadHunter Assay - FR
Item
5917
Protein
GluN2A
Organism
Human
Assay Sub Type
Cell Based
Family
NHR
Name
ERalpha Human Estrogen NHR Cell Based Antagonist Reporter LeadHunter Assay - FR
Item
5919
Protein
ERalpha
Organism
Human
Assay Sub Type
Cell Based
Family
NHR
Name
GR Human Glucocorticoid NHR Cell Based Antagonist Reporter LeadHunter Assay - FR
Item
5920
Protein
GR
Organism
Human
Assay Sub Type
Cell Based
Family
Kinase
Name
PDHK1 (PDK1) Human Kinase Other protein Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5925
Protein
PDK1
Organism
Human
Assay Sub Type
Enzymatic
Family
Ion Channel
Name
KCNQ1 KvLQT1/minK Human Potassium Ion Channel Thallium Flux Cell Based Antagonist LeadHunter - FR
Item
5941
Protein
KCNQ1
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
nAChR (Alpha1, Muscle-Type) Human Acetylcholine (Nicotinic) Ion Channel Cell Based Agonist LeadHunter Assay - FR
Item
5949
Protein
nAChR a1
Organism
Human
Assay Sub Type
Cell Based
Family
Ion Channel
Name
nAChR (Alpha1, Muscle-Type) Human Acetylcholine (Nicotinic) Ion Channel Cell Based Antagonist LeadHunter Assay - FR
Item
5950
Protein
nAChR a1
Organism
Human
Assay Sub Type
Cell Based
Family
Enzyme
Name
Cathepsin D Human Pepsin Aspartic Peptidase Enzymatic LeadHunter Assay - FR
Item
650
Protein
Cathepsin D
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
D3 Human Dopamine GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
683
Protein
D3
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
D3 Human Dopamine GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
684
Protein
D3
Organism
Human
Assay Sub Type
Cell Based
Family
NHR
Name
AR Human Androgen NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
933
Protein
AR
Organism
Human
Assay Sub Type
Binding
Testing Information
Test Sample Requirements:
500 µL of a 333× DMSO stock solution, calculated from the top concentration to be tested (PBS working solutions are not compatible)
Turnaround Time
Standard:
15 Business Days
Additional Information
Brand:
SafetyScreen
Testing Location:
France - Celle L'Evescault
Other Information:
Available on demand in single-concentration screening format. Contact us for more information : ClientServicesPoitiers@discovery.eurofinseu.com
Please see Related Solutions below for more panels formats.
RELATED SOLUTIONS
SafetyScreen18 Core Panel - FR
Item: P447
SafetyScreen59 Extended Panel - FR
Item: P448
SafetyScreen77 Core Extended Panel - FR
Item: P456
SafetyScreen77 Functional Core Extended Panel - FR
Item: P460-EU
SafetyScreen18 Functional Core Panel - FR
Item: P452-EU
Questions? Contact Us
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