Translational Biology Approaches

Streamline Clinical Translation of Your Biologics with Functional In Vitro Assessments

Eurofins Discovery is a leader in human-focused phenotypic screening, profiling, and translational biology assays and services, enabling you to generate clinically relevant insights to advance your pipeline. Our cell-based functional approaches cover a wide range of therapeutic areas, from cardiovascular disease to oncology.
 
Translational biology approaches continue to provide powerful screening and profiling option to prioritize hits and lead biotherapeutics, identify safety liabilities and immunogenicities, and develop commercially successful biologics for unmet medical needs. The renaissance in phenotypic testing is justified: The approach provides a preview in models that closely mimic human disease states and, therefore patients. These insights are invaluable at all stages of preclinical drug development, expediting biotherapeutics discovery programs.
 
Eurofins Discovery drives the phenotypic renaissance forward with human cell-based disease models for important therapeutic areas in oncology, immunology, inflammation, and cardiovascular disease. We generate biologically relevant data for your complex, multi-dimensional biotherapeutics and the complicated biology they target, enabling better decision making and empowering you to succeed quickly. We connect our translational biology assays to specific clinical outcomes and optimize cell type, culture conditions, format, and endpoints for relevance to the human data you care most about.

Key Areas

The BioMAP® Platform provides response profiles in human primary cell-based disease models. A robust reference database powers advanced analytics.

Features 2D or 3D spheroid cancer models with genomic tools for evaluation of innovations and combinations.

Evaluate mechanistic and functional readouts. By testing candidates in diverse cellular contexts with ELISA, Alpha LISA, Meso Scale Discovery®, Luminex, and more.

Critical and early identification of toxicities and adverse outcome risks with BioMAP® Toxicity Signature Analysis and cytokine release assay strategies.

Small molecule or biotherapeutics assessment on adaptive immunity with BioMAP T Cell Autoimmune Panel, Cytokine Storm, and AdapTive models.

Not just about variety, these assays are about context, with 3D spheroids, tumor microenvironment models for immuno-oncology, and cell migration assays.

Features