Biological Information

Background Information:

Evaluation of the agonist activity of compounds at the human Glucagon receptor, determined by measuring their effect on cAMP production.

The Glucagon receptor (gene name: GCGR) is part of the Glucagon receptor family which comprises also the GHRH, GIP, GLP-1, GLP-2 and Secretin receptors.

Family:

GPCR

Sub Family:

Glucagon

Class:

Class B

Protein Name:

Glucagon

Uniprot Number:

P47871

Protein Aliases:

Glucagon

Gene Name:

GCGR

Gene ID:

2642

Gene Aliases:

GGR

Accession Number:

NM_000160

Organism:

Human

Assay Information

Assay Type:

Functional

Assay Sub Type:

Cell Based

Functional Mode:

Agonist

Detection Method:

HTRF

Measured Response:

AMPc

Testing Information

Incubation:

15 min at 22 °C

Control Activator:

Glucagon

Minimum Order Quantity:

16

Turnaround Time

Standard:

15 Business Days

Reference Compound Data

PubChem ID

16132283

Name

Glucagon

Measurement

0.0292nM - EC50

PubChem ID

171378578

Name

Retatrutide

Measurement

1.16nM - EC50

PubChem ID

156588324

Name

Tirzépatide

Measurement

- EC50

PubChem ID

56843331

Name

Semaglutide

Measurement

- EC50

Clinical Relevance

Therapeutic Area:

Metabolic Diseases

Additional Information

Brand:

LeadHunter

Testing Location:

France - Celle L'Evescault

RELATED SOLUTIONS

Item: 1840
Item: G437