Biological Information

Background Information:

Evaluation of the agonist activity of compounds at the human Glucagon receptor, determined by measuring their effect on cAMP production.

The Glucagon receptor (gene name: GCGR) is part of the Glucagon receptor family which comprises also the GHRH, GIP, GLP-1, GLP-2 and Secretin receptors.

Family:

GPCR

Sub Family:

Glucagon

Class:

Class B

Protein Name:

Glucagon

Uniprot Number:

P47871

Protein Aliases:

Glucagon

Gene Name:

GCGR

Gene ID:

2642

Gene Aliases:

GGR

Accession Number:

NM_000160

Organism:

Human

Assay Information

Assay Type:

Functional

Assay Sub Type:

Cell Based

Functional Mode:

Antagonist

Detection Method:

HTRF

Testing Information

Incubation:

15 min at 22 °C

Minimum Order Quantity:

16

Turnaround Time

Standard:

15 Business Days

Reference Compound Data

PubChem ID

5311276

Name

L-168,049

Measurement

3520nM - IC50

PubChem ID

16133829

Name

[Des-His1, Glu9]-Glucagon amide

Measurement

146nM - IC50

PubChem ID

16198321

Name

exendin-3(9-39)

Measurement

- IC50

PubChem ID

44625560

Name

LGD-6972

Measurement

1900nM - IC50

Clinical Relevance

Therapeutic Area:

Metabolic Diseases

Additional Information

Brand:

LeadHunter

Testing Location:

France - Celle L'Evescault

RELATED SOLUTIONS

Item: 1839
Item: G437