GABAB (B1b/B2) Human GABAB GPCR Mass Spectrometry Binding Antagonist ligand LeadHunter Assay - FR

Background Information:

GABA is the major inhibitory transmitter in the mammallian central nervous system. GABAB receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. GABAB receptors are located on pre- and postsynaptic neurones in the central nervous system and peripheral autonomic nerve fibers and sensory fibers.

Family:

GPCR

Sub Family:

GABAB

Class:

Class C

Protein Name:

GABAB (B1/B2)

Uniprot Number:

Q9UBS5/O75899

Protein Aliases:

GABA-B receptor

Gene Name:

GABBR1/GABBR2

Gene ID:

2550/9568

Gene Aliases:

GB1; hGB1a; GPRC3A; GABABR1; GABBR1-3

Organism:

Human