FAK Human TK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR

Background Information:

PTK2 (Protein Tyrosine Kinase 2, formerly FAK or Focal Adhesion Associated Protein Tyrosine Kinase) is a widely expressed nonreceptor involved in the structure and function of focal adhesions, which are critical for cellular integrity by maintaining cell-cell and cell-matrix interactions. Integrin-mediated cell adhesion causes activation of MAP kinases and increased tyrosine phosphorylation of PTK2. Autophosphorylation of PTK2 leads to the binding of SH2-domain proteins including Src-family kinases and the Grb2-Sos complex, then activate Ras cascade and ultimately to mitogen activated protein (MAP) kinase activation.

Family:

Kinase

Sub Family:

TK

Class:

Protein Tyrosine

Protein Name:

FAK

Uniprot Number:

Q05397

Protein Aliases:

protein phosphatase 1, regulatory subunit 71

Gene Name:

PTK2

Gene ID:

5747

Gene Aliases:

FAK, FADK, FAK, PPP1R71

Accession Number:

L13616

Organism:

Human