Caspase 7 Human Caspase Cysteine Peptidase Enzymatic LeadHunter Assay - TW

Background Information:

Caspases are the executioners of programmed cell death (apoptosis), a normal process used physiologically to eliminate specific cells or cell types without damaging surrounding cells or causing an inflamatory response. All caspases belong to a family of proteases characterized by a cysteine residue in the active site and display specificity for Asp residues. Caspases are present in all cells as a procaspase, which becomes activated through proteolytic cleavage by other proteases including other caspases. Caspase-7 (Mch3, ICE-LAP3, CMH-1) has two splice isoforms, one of which can act as a negative regulator of apoptosis. Caspase-7 is widely expressed in the body, with lowest expression levels in the brain. Caspase inhibitors are currently sought as therapeutics for such diseases as Alzheimer's, Parkinson's and cerebral/myocardial ischemia.

Family:

Protease

Sub Family:

Caspase

Class:

Cysteine Peptidase

Protein Name:

Caspase 7

Uniprot Number:

P55210

Gene Name:

CASP7

Gene ID:

840

Gene Aliases:

MCH3|CMH-1|ICE-LAP3

Accession Number:

NM_033338

Organism:

Human

Construct Details:

Fragment, Recombinant