Biological Information

Background Information:

Caspases are a kind of cysteine proteases, which can cleave their target proteins at aspartic acid residues. With their proteolytic functions related to apoptosis and inflammatory pathways, abnormal caspase activity can result in neurodegenerative and inflammatory diseases. Caspase inhibitors include pseudosubstrates and allosteric inhibitors, which are widely used for neurological diseases, inflammatory diseases, and metabolic diseases research.

No. of Assays on Panel:

10

Assays on Panel:

Family

Protease

Name

Item

163100

Protein

Caspase 2

Organism

Human

Assay Sub Type

Enzymatic

Family

Protease

Name

Item

163200

Protein

Caspase 3

Organism

Human

Assay Sub Type

Enzymatic

Family

Protease

Name

Item

163240

Protein

Caspase 4

Organism

Human

Assay Sub Type

Enzymatic

Family

Protease

Name

Item

163280

Protein

Caspase 5

Organism

Human

Assay Sub Type

Enzymatic

Family

Protease

Name

Item

163300

Protein

Caspase 6

Organism

Human

Assay Sub Type

Enzymatic

Family

Protease

Name

Item

163400

Protein

Caspase 7

Organism

Human

Assay Sub Type

Enzymatic

Family

Protease

Name

Item

163500

Protein

Caspase 8

Organism

Human

Assay Sub Type

Enzymatic

Family

Protease

Name

Item

163600

Protein

Caspase 9

Organism

Human

Assay Sub Type

Enzymatic

Family

Protease

Name

Item

163700

Protein

Caspase 10

Organism

Human

Assay Sub Type

Enzymatic

Family

Protease

Name

Item

199011

Protein

Caspase 1

Organism

Human

Assay Sub Type

Enzymatic

Family:

Protease

Sub Family:

Caspase

Class:

Cysteine Peptidase

Assay Information

Assay Type:

Biochemical

Assay Sub Type:

Enzymatic

Testing Information

Test Concentration / Dose:

Suggested concentration for initial testing is 10 µM

Test Sample Requirements:

100 μl of a 10 mM stock or 1 mg pre-weighed powder (assuming FW≦500 and purity 100%)

Turnaround Time

Standard:

15 Business Days

Clinical Relevance

Therapeutic Area:

Inflammation/Allergy

Additional Information

Brand:

LeadHunter

Testing Location:

Taiwan - Taipei