Caspase 1 Human Caspase Cysteine Peptidase Enzymatic LeadHunter Assay - TW

Background Information:

Caspases are the executioners of programmed cell death (apoptosis), a normal process used physiologically to eliminate specific cells or cell types without damaging surrounding cells or causing an inflammatory response. All caspases belong to a family of proteases characterized by a cysteine residue in the active site and display specificity for Asp residues. Caspases are present in all cells as a procaspase, which becomes activated through proteolytic cleavage by other proteases including other caspases. Caspase-1 (interleukin-1 beta-converting enzyme, ICE) is responsible for proteolytic activation of the biologically inactive interleukin-1 beta precursor to the proinflammatory cytokine. Inhibition of ICE is a new anti-inflammatory strategy being explored by the design of both reversible inhibitors and irreversible inactivators of the enzyme. ICE inhibitors that cross react against multiple ICE homologs can also block diverse types of apoptosis.

Family:

Protease

Sub Family:

Caspase

Class:

Cysteine Peptidase

Protein Name:

Caspase 1

Uniprot Number:

P29466

Protein Aliases:

caspase-1|interleukin 1, beta, convertase

Gene Name:

CASP1

Gene ID:

834

Gene Aliases:

ICE

Accession Number:

NM_033292

Organism:

Human

Construct Details:

Fragment, Recombinant