5-HT3a Human Serotonin Ion Channel Functional Cell Based Agonist Calcium Flux LeadHunter Assay - FR

Background Information:

Serotonin 5-HT receptors belong to the superfamily of G protein-coupled seven transmembrane proteins with the exception of the 5-HT3 subtype, which belongs to the ligand gated cation superfamily of receptors. Serotonin 5-HT3 receptors appear to be present exclusively in neural tissue. Serotonin 5-HT3 receptor agonism may reduce water intake, cause hyperglycemia, facilitate gastric emptying and emesis. Receptor antagonism may prevent nausea and vomiting induced by cancer chemotherapy, diarrhea-predominant IBS and cause headache.

Family:

Ion Channel

Sub Family:

Serotonin

Class:

Ligand-Gated

Protein Name:

5-HT3A

Uniprot Number:

P46098

Protein Aliases:

5-hydroxytryptamine receptor 3 (5-HT-3; 5-HT3R), Serotonin receptor 3A, Serotonin-gated ion channel receptor

Gene Name:

HTR3A

Gene ID:

3359

Gene Aliases:

5-hydroxytryptamine (serotonin) receptor 3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropi

Organism:

Human

Cell Type:

CHO-K1