OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Adrenoreceptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Adrenoreceptors are found in most peripheral tissue and within the central nervous system.
Family:
GPCR
Sub Family:
Adrenoceptor
Class:
Class A
Protein Name:
alpha1D
Uniprot Number:
P25100
Protein Aliases:
Alpha-1D adrenoreceptor|Alpha-1D adrenoceptor|Alpha-adrenergic receptor 1a
Gene Name:
ADRA1D
Gene ID:
146
Gene Aliases:
ADRA1R|ADRA1A|ADRA1
Accession Number:
NM_000678
Organism:
Human
Construct Details:
Recombinant
Cell Type:
Chem-1
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Antagonist
Detection Method:
Fluorimetry
Measured Response:
Fluorescence
Testing Information
Incubation:
RT
Control Inhibitor:
WB-4101 hydrochloride
Control Activator:
epinephrine (10 nM)
Test Concentration / Dose:
Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.
Test Sample Requirements:
Minimum for 1) Screen: 70 µL of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM finµL testing. 2) Dose Response: 90 µL of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
16
Turnaround Time
Standard:
15 Business Days
Reference Compound Data
Clinical Relevance
Therapeutic Area:
Cardiovascular
Adverse / Beneficial Action:
Adrenergic a1D receptor antagonism may be useful in the treatment of hypertension with minimal associated orthostatic hypotension.
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
RELATED SOLUTIONS
alpha1D Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item: 1942
alpha1D Human Adrenoceptor GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item: 4219
alpha1D Human Adrenoceptor GPCR Cell Based Agonist & Antagonist Calcium Flux LeadHunter Assay - FR
Item: G250
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