A2B Human Adenosine GPCR Cell Based Antagonist cAMP LeadHunter Assay - TW

Background Information:

Adenosine receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Adenosine receptors may also be called P1 receptors, which are distinguished from transmitter-gated ion channels (P2X receptors) and G protein-coupled receptors (P2Y). Adenosine A2B receptor agonism may cause vascular and intestinal smooth muscle relaxation, antagonism may be useful in the treatment of pulmonary inflammation associated with asthma.

Family:

GPCR

Sub Family:

Adenosine

Class:

Class A

Protein Name:

A2B

Uniprot Number:

P29275

Gene Name:

ADORA2B

Gene ID:

136

Accession Number:

XM_017024197

Organism:

Human

Construct Details:

Full Length, Recombinant

Cell Type:

CHO-K1