Proteomics allows for in-depth analysis of the entire set of proteins expressed by a genome, known as the proteome. In the transformative landscape of drug discovery, proteomics emerges as a critical tool that reshapes how we develop, assess, and optimize drugs, leading to groundbreaking therapeutic advancements. Eurofins Discovery offers comprehensive proteomics solutions, equipping you with the tools to create therapies that are more effective, safer, and highly personalized.
Target Evaluation: A New Era of Precision
Proteomics analysis is crucial for identifying and validating drug targets, ensuring that new therapeutics are precisely aimed at the biological mechanisms underlying disease. By focusing on the right targets, drugs are developed with a higher likelihood of success, reducing the time and cost associated with drug development.
Drug Safety: Predicting and Mitigating Risks
Understanding the protein interactions influenced by a drug can predict potential side effects and toxicities. This knowledge is pivotal in designing safer drugs, reducing adverse effects, and ensuring patient safety. By comprehensively profiling a drug’s impact on the proteome, researchers can make informed decisions about a drug’s safety profile early in the development process.
Drug Repurposing: Uncovering Hidden Potential
By analyzing how existing drugs interact with various proteins, researchers can uncover new therapeutic uses for these drugs. This approach can significantly speed up the availability of treatments for various conditions, as these drugs have already undergone extensive safety testing.
Cell Therapy Development: Enhancing Efficacy and Safety
By identifying specific molecular pathways and biomarkers, proteomics can guide the design and customization of more effective cell therapies. And proteomics contributes to the refinement of cell therapy products by ensuring their molecular consistency and stability, vital for patient safety and treatment efficacy. You can rely on Eurofins Discovery’s experience and expertise to deliver comprehensive proteomics with both traditional and advanced proteomics solutions.
Figure 1. Eurofins Discovery Proteomics Service Applications and Workflow. The proteomics approach identifies and quantifies proteins collectively in the samples across comparative groups. In this method, proteins from cells, animal, or human tissues are extracted, digested into peptides, and analyzed using a top-of-the-line Mass Spectrometry (MS) and nano-Liquid Chromatography (nano-LC) system. We offer both traditional and advanced proteomics solutions, allowing for customized designs. The proteins with significant abundance changes are categorized according to the biological processes, cellular components, and molecular functions in gene ontology analysis. The approach characterizes drug on-target or off-target effects and identifies biomarkers for disease prognosis, diagnosis, or therapeutic efficacy.
