Comprehensive Evaluation for Discovery, Development, and Repurposing
- Benefit from quantitative assessment of small molecule or biologic influence on 35+ clinically relevant protein biomarkers, including cell surface membrane receptors, chemokines, cytokines, and measures of cell health
- Select from one, two, or three systems to report on adaptive immune responses in lymph, systemic, or tissue environments
- Evaluate tissue responses relevant to clinical disease including: COVID-19, acute respiratory distress syndrome, viral pneumonia, pulmonary inflammation
- Gain actionable insights from heat map visualizations of datasets that summarize results from each model
Figure 1. Overview of three available human primary cell-based adaptive immune response models with cell surface receptor, cell health, chemokine, and pro-inflammatory cytokine biomarker readouts relevant for acute and chronic inflammatory biology. AdapT-B models T cell dependent B cell proliferation and activation in secondary lymphoid tissues, AdapT-E models chronic inflammation-driven T cell effector responses in the content of activated vascular endothelium, and AdapT-F models chronic inflammation-driven T cell effector responses in the context of peripheral tissue. Each system is stimulated with a T cell receptor agonist cocktail that includes staphylococcal enterotoxin B (SEB) plus toxic shock syndrome toxin-1 (TSST-1); AdapT-B is also stimulated with anti-IgM antibody.
