TEC Human Kinase SH2 Domain-Containing SH2scan KdELECT Binding LeadHunter Assay - US

Background Information:

Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. (https://www.uniprot.org/uniprotkb/P42680/entry). SH2-domain binding assays were developed using Eurofins Discovery's proprietary KINOMEscan technology that utilizes DNA-tagged target proteins and a high sensitivity qPCR readout to enable highly sensitive (accurate ligand KDs measured down to low picomolar range) and quantitative competition binding assays.

Family:

Kinase

Sub Family:

TK

Class:

Protein Tyrosine

Protein Name:

TEC

Uniprot Number:

P42680

Gene Name:

TEC

Gene ID:

7006

Gene Aliases:

PSCTK4

Accession Number:

NP_003206.2

Organism:

Human

Construct Details:

Wild Type; Partial Length (Start/Stop:T235/T355); Mammalian Expression