TAF1L (2) Human Bromodomain-Containing Cell Based Agonist Binding LeadHunter Assay - US

Background Information:

The InCELL Hunter technology measures intracellular compound-target engagement by detecting changes in protein stability due to compound binding. In this assay, the target is fused to the enhanced ProLabel™(ePL) enzyme fragment and expressed in the selected cell background. The amount of fusion is quantified through the addition of substrate and complementary enzyme acceptor fragment (EA). The small size, but robust activity of the ePL tag makes it an ideal fusion partner. The small disordered peptide has minimal effects on target half-life, and generates high levels of enzyme activity, resulting in a sensitive measurement of protein levels.

Family:

Kinase

Class:

Atypical

Protein Name:

TAF1L

Uniprot Number:

Q8IZX4

Protein Aliases:

II210|TBP-associated factor 1-like|TBP-associated factor 210 kDa|Transcription initiation factor TFIID 210 kDa subunit

Gene Name:

TAF1L

Gene ID:

138474

Accession Number:

NM_153809.2

Organism:

Human

Cell Type:

HEK293