STAT2 Human SH2 Domain-Containing SH2scan KdELECT Binding LeadHunter Assay - US

Background Information:

Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively. (https://www.uniprot.org/uniprotkb/P52630/entry). SH2-domain binding assays were developed using Eurofins Discovery's proprietary KINOMEscan technology that utilizes DNA-tagged target proteins and a high sensitivity qPCR readout to enable highly sensitive (accurate ligand KDs measured down to low picomolar range) and quantitative competition binding assays.

Family:

Immune System

Sub Family:

Transcription Factor

Class:

STAT

Protein Name:

STAT2

Uniprot Number:

P52630

Gene Name:

STAT2

Gene ID:

6773

Gene Aliases:

STAT113

Accession Number:

NP_005410.1

Organism:

Human

Construct Details:

Wild Type; Partial Length (Start/Stop:G130/L706); Mammalian Expression