SOCS6 Human SH2 Domain-Containing SH2scan ELECT Binding LeadHunter Assay - US

Background Information:

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. (https://www.uniprot.org/uniprotkb/O14544/entry). SH2-domain binding assays were developed using Eurofins Discovery's proprietary KINOMEscan technology that utilizes DNA-tagged target proteins and a high sensitivity qPCR readout to enable highly sensitive (accurate ligand KDs measured down to low picomolar range) and quantitative competition binding assays.

Family:

Adaptor

Sub Family:

Suppressors of Cytokine Signaling (SOCS)

Class:

SH2 domain containing

Protein Name:

SOCS6

Uniprot Number:

O14544

Gene Name:

SOCS6

Gene ID:

9306

Gene Aliases:

CIS4|SSI4|HSPC060|STATI4|STAI4|Cish4

Accession Number:

NP_004223.2

Organism:

Human

Construct Details:

Wild Type; Partial Length (Start/Stop:V361/S499); Mammalian Expression