PIK3R3 C-term Human Kinase SH2 Domain-Containing SH2scan ELECT Binding LeadHunter Assay - US

Background Information:

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. (https://www.uniprot.org/uniprotkb/Q92569/entry). SH2-domain binding assays were developed using Eurofins Discovery's proprietary KINOMEscan technology that utilizes DNA-tagged target proteins and a high sensitivity qPCR readout to enable highly sensitive (accurate ligand KDs measured down to low picomolar range) and quantitative competition binding assays.

Family:

Kinase

Sub Family:

PtdIns(4,5)P 3-Kinase

Class:

Lipid

Protein Name:

PIK3R3 (p55gamma)

Uniprot Number:

Q92569

Protein Aliases:

phosphoinositide-3-kinase regulatory subunit gamma

Gene Name:

PIK3R3

Gene ID:

8503

Gene Aliases:

p55

Accession Number:

NP_001290357.1

Organism:

Human

Construct Details:

Wild Type; Partial Length (Start/Stop:N366/C477); Mammalian Expression