PDHK1 Human PDHK Kinase Enzymatic ADP-Glo [10 μM ATP] Kinase LeadHunter Assay - TW

Background Information:

PDHK1 (pyruvate dehydrogenase kinase 1) is a mitochondrial enzyme that regulates cellular metabolism by inhibiting the pyruvate dehydrogenase (PDH) complex. It phosphorylates and inactivates PDH, controlling pyruvate entry into the TCA cycle and balancing glycolysis and oxidative phosphorylation. Regulated by hormones, nutrients, and oxygen levels, PDHK1 is crucial for glucose homeostasis, energy production, and metabolic adaptation. As a key metabolic regulator, it's a potential therapeutic target for metabolic disorders, cancer, and other diseases characterized by aberrant cellular metabolism. PDHK1 enhancement may protect cognitive recovery, while its inhibition is associated with various disorders, including abnormal myelination, hypoglycemia, ketoacidosis, seizures, and peripheral neuropathy.

Family:

Kinase

Sub Family:

PDHK

Class:

Atypical

Protein Name:

PDHK1

Uniprot Number:

Q15118

Protein Aliases:

Pyruvate dehydrogenase kinase isoform 1 (PDH kinase 1)

Gene Name:

PDK1

Gene ID:

5163

Gene Aliases:

pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1

Accession Number:

NM_002610

Organism:

Human

Construct Details:

Full length, recombinant