OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
This specialized panel includes a total of six enzymatic assays for poly (ADP-ribose) polymerase (PARP) superfamily members, including PARP1, PARP2, PARP3, PARP5A (TNKS1), PARP5B (TNKS2), and PARP7. These six PARP subtypes play a crucial role in DNA repair (PARP1, PARP2, PARP3), Wnt signaling pathway (PARP5A, PARP5B), and innate immune regulation (PARP7), which serves as an emerging therapeutic strategy against various cancer types. Notably, selective PARP inhibitors are highly engaged in the treatment of BRCA-mutated ovarian, breast, and prostate cancers as well as advanced solid tumors. By screening this panel, potential selective PARP inhibitors can be evaluated and identified.
No. of Assays on Panel:
6
Assays on Panel:
Family
DNA Repair & Mitotic Regulation
Name
Poly (ADP-ribose) Polymerase 1 (PARP1) Human Enzymatic LeadHunter Assay - TW
Item
166801
Protein
PARP1
Organism
Human
Assay Sub Type
Enzymatic
Family
DNA Repair & Mitotic Regulation
Name
Poly (ADP-ribose) Polymerase 2 (PARP2) Human Enzymatic LeadHunter Assay - TW
Item
166811
Protein
PARP2
Organism
Human
Assay Sub Type
Enzymatic
Family
DNA Repair & Mitotic Regulation
Name
Poly (ADP-ribose) Polymerase 3 (PARP3) Human Enzymatic LeadHunter Assay - TW
Item
166820
Protein
PARP3
Organism
Human
Assay Sub Type
Enzymatic
Family
DNA Repair & Mitotic Regulation
Name
Poly (ADP-ribose) Polymerase 5A (PARP5A) Human Enzymatic LeadHunter Assay - TW
Item
166840
Protein
PARP5A
Organism
Human
Assay Sub Type
Enzymatic
Family
DNA Repair & Mitotic Regulation
Name
Poly (ADP-ribose) Polymerase 5B (PARP5B) Human Enzymatic LeadHunter Assay - TW
Item
166850
Protein
PARP5B
Organism
Human
Assay Sub Type
Enzymatic
Family
DNA Repair & Mitotic Regulation
Name
Poly (ADP-ribose) Polymerase 7 (PARP7) Human Enzymatic LeadHunter Assay - TW
Item
166870
Protein
PARP7
Organism
Human
Assay Sub Type
Enzymatic
Class:
Protein (enzyme)
Assay Information
Assay Type:
Biochemical
Assay Sub Type:
Enzymatic
Testing Information
Test Concentration / Dose:
Suggested concentration for initial testing is 10 µM
Test Sample Requirements:
50 μl of a 10 mM stock or 1 mg pre-weighed powder (assuming FW≦500 and purity 100%)
Turnaround Time
Standard:
10 Business Days
Additional Information
Brand:
LeadHunter
Testing Location:
Taiwan - Taipei
Questions? Contact Us
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