OX1 Human Orexin GPCR Binding Agonist Radioligand LeadHunter Assay - FR

Background Information:

Orexins, also called hypocretins, are the common names given to a pair of highly excititory neuropeptide hormone. Two highly-related peptides (Orexin A and B) are produced by cleavage of a single precursor protein. Both peptides bind to two G-protein coupled receptors, orexin-1 (OX1) and orexin-2 (OX2). The orexin receptors are located predominantly in the hypothalamus and locus coeruleus, but are also found elsewhere in the CNS. The orexins have been linked to a range of physiological functions including the control of feeding and energy metabolism, modulation of neuroendocrine function, and regulation of the sleep-wake cycle. Orexin OX1 recetor antagonism may useful for the treatment of insomnia and obesity.

Family:

GPCR

Sub Family:

Orexin

Class:

Class A

Protein Name:

OX1

Uniprot Number:

O43613

Protein Aliases:

orexin receptor 1

Gene Name:

HCRTR1

Gene ID:

3061

Gene Aliases:

OX1R

Accession Number:

NM_001525

Organism:

Human

Construct Details:

Recombinant