OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Metabolic dysfunction-associated steatohepatitis (MASH), formerly known as non-alcoholic steatohepatitis (NASH), is the severe form of MASLD (metabolic dysfunction-associated steatotic liver disease), which affects almost 25% of the world population with a high overlap of obesity and diabetes. The pathogenesis of MASH is complex in association with steatosis and hepatitis, followed by aggressive fibrosis, cirrhosis, and even cancer. This specialized panel contains a total of 29 targets, which are highly engaged in glucose (e.g., GLP1), lipid (e.g., THRβ), and bile acid (e.g., FXR) metabolisms, as well as inflammatory (e.g., VAP1), apoptotic (e.g., ASK1), and fibrotic (e.g., LOXL2) effects, all are critical therapeutic indicators for MASH drug discovery and development. This panel enables an understanding of the mechanism of action (MOA), which helps more efficacious drugs discovered against this difficult-to-treat liver disease.
No. of Assays on Panel:
29
Assays on Panel:
Family
Lipid Metabolism
Name
Acetyl-coenzyme A carboxylase 1 Human Enzymatic LeadHunter Assay - TW
Item
101800
Protein
ACC1
Organism
Human
Assay Sub Type
Enzymatic
Family
Lipid Metabolism
Name
Lipase Human Enzymatic LeadHunter Assay - TW
Item
133000
Protein
Lipase
Organism
Human
Assay Sub Type
Enzymatic
Family
Oxidoreductase
Name
Lysyl Oxidase Homolog 2 (LOXL2) Enzymatic LeadHunter Assay - TW
Item
138700
Protein
LOXL2
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
Caspase 3 Human Caspase Cysteine Peptidase Enzymatic LeadHunter Assay - TW
Item
163200
Protein
Caspase 3
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
Caspase 7 Human Caspase Cysteine Peptidase Enzymatic LeadHunter Assay - TW
Item
163400
Protein
Caspase 7
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
Caspase 8 Human Caspase Cysteine Peptidase Enzymatic LeadHunter Assay - TW
Item
163500
Protein
Caspase 8
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
ASK1 Human STE Kinase Enzymatic Radiometric LeadHunter Assay [10 μM ATP] - TW
Item
167150
Protein
ASK1
Organism
Human
Assay Sub Type
Enzymatic
Family
Free Radical Scavenger
Name
Free Radical Scavenger Bovine SOD Mimetic Enzymatic LeadHunter Assay - TW
Item
193500
Protein
Organism
Bovine
Assay Sub Type
Enzymatic
Family
Oxidoreductase
Name
VAP-1/AOC3 Human Enzymatic LeadHunter Assay - TW
Item
197000
Protein
Vascular adhesion protein 1
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
Dipeptidyl Peptidase 4 Human Prolyl Oligopeptidase Serine Peptidase Enzymatic LeadHunter Assay - TW
Item
199007
Protein
DPP4
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
Caspase 1 Human Caspase Cysteine Peptidase Enzymatic LeadHunter Assay - TW
Item
199011
Protein
Caspase 1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
AMPK Human PRKAA1 Kinase Enzymatic Radiometric Activation LeadHunter Assay [1 μM ATP] - TW
Item
199100-0
Protein
AMPK
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
CCR2 Human Chemokine GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
217550
Protein
CCR2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CCR5 Rhesus Macaque Chemokine GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
217730
Protein
CCR5
Organism
Rhesus Macaque
Assay Sub Type
Binding
Family
GPCR
Name
Glucagon Human Glucagon GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
231680
Protein
GCGR
Organism
Human
Assay Sub Type
Binding
Family
Cell Surface (Other)
Name
IL-1 R1 Human Interleukin Binding Agonist Radioligand LeadHunter Assay - TW
Item
243530
Protein
IL-1R-1
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
PPARgamma Human NHR Binding Agonist Radioligand LeadHunter Assay - TW
Item
267500
Protein
PPARgamma
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
TR Beta Human Thyroid Hormone NHR Binding Agonist Radioligand LeadHunter Assay - TW
Item
285940
Protein
THRB
Organism
Human
Assay Sub Type
Binding
Family
Kinase
Name
TGFbeta (Non-Selective) Mouse TKL Kinase Binding Agonist Radioligand LeadHunter Assay - TW
Item
286200
Protein
Organism
Mouse
Assay Sub Type
Binding
Family
GPCR
Name
GPBA (TGR5) Human Bile Acid GPCR Cell Based Agonist cAMP LeadHunter Assay - TW
Item
304110-0
Protein
GPBAR
Organism
Human
Assay Sub Type
Cell Based
Family
NHR
Name
FXR Human Liver X Receptor-Like NHR Functional Agonist Coactivator LeadHunter Assay - TW
Item
311600-0
Protein
FXR
Organism
Human
Assay Sub Type
Protein-Protein Interaction
Family
GPCR
Name
FFA1 (GPR40) Human Free Fatty Acid GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - TW
Item
311810-0
Protein
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
GIP Human Glucagon GPCR GTPgammaS Agonist LeadHunter Assay - TW
Item
312980-0
Protein
GIP-R
Organism
Human
Assay Sub Type
GTPgammaS
Family
GPCR
Name
GLP-1 Human Glucagon GPCR GTPgammaS Agonist LeadHunter Assay - TW
Item
313010-0
Protein
GLP-1R
Organism
Human
Assay Sub Type
GTPgammaS
Family
NHR
Name
PPARalpha Human NHR Functional Agonist Coactivator Assay, Panlabs
Item
338210-0
Protein
PPARalpha
Organism
Human
Assay Sub Type
Protein-Protein Interaction
Family
NHR
Name
PPARdelta Human NHR Cell Based Agonist Protein-Protein Interaction LeadHunter Assay - TW
Item
338260-0
Protein
Organism
Human
Assay Sub Type
Cell Based
Family
Kinase
Name
FGFR1b-Klotho Human RTK Kinase Cell Based Agonist Functional LeadHunter Assay - TW
Item
339210-0
Protein
Organism
Human
Assay Sub Type
Cell Based
Family
Kinase
Name
FGFR4-b-Klotho Human RTK Kinase Cell Based Agonist Functional LeadHunter Assay - TW
Item
339240-0
Protein
Organism
Human
Assay Sub Type
Cell Based
Family
NHR
Name
Keap1-Nrf2 Human Transcription Factor Cell Based Agonist Nuclear Translocation LeadHunter Assay - TW
Item
362000-0
Protein
NRF2
Organism
Human
Assay Sub Type
Cell Based
Testing Information
Test Concentration / Dose:
Suggested concentration for initial testing is 10 µM
Test Sample Requirements:
520 μL of a 10 mM stock or 3 mg pre-weighed powder (assuming FW≦500 and purity 100%)
Turnaround Time
Standard:
20 Business Days
Additional Information
Brand:
LeadHunter
Testing Location:
Taiwan - Taipei
Questions? Contact Us
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