JAK2 (JH2domain-pseudokinase, V617F) Human TK Kinase KINOMEscan ELECT Binding LeadHunter Assay - US

Background Information:

Janus kinase 2 (JAK2) is a nonreceptor tyrosine kinase belonging to the Janus family. It is activated by a variety of cytokine and growth factor receptors, resulting in signaling cascades that facilitate the activation of various downstream target genes. JAK2 mediates gene transcription through its well-characterized downstream signaling molecules, the signal transducers and activators of transcription proteins (STAT).

Family:

Kinase

Sub Family:

TK

Class:

Protein Tyrosine

Protein Name:

JAK2

Uniprot Number:

O60674

Protein Aliases:

JAK-2

Gene Name:

JAK2

Gene ID:

3717

Gene Aliases:

JTK10

Accession Number:

NP_004963.1

Organism:

Human

Construct Details:

Mutant (V617F); Partial Length (Start/Stop: R513/N824); Mammalian Expression