GRB2 Human SH2 Domain-Containing SH2scan ELECT Binding LeadHunter Assay - US

Background Information:

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. (https://www.uniprot.org/uniprotkb/P62993/entry). SH2-domain binding assays were developed using Eurofins Discovery's proprietary KINOMEscan technology that utilizes DNA-tagged target proteins and a high sensitivity qPCR readout to enable highly sensitive (accurate ligand KDs measured down to low picomolar range) and quantitative competition binding assays.

Family:

Adaptor

Sub Family:

Signal Transducing Adaptor Protein (STAP)

Class:

SH2 domain containing

Protein Name:

GRB2

Uniprot Number:

P62993

Gene Name:

GRB2

Gene ID:

2885

Gene Aliases:

NCKAP2

Accession Number:

NP_002077.1

Organism:

Human

Construct Details:

Wild Type; Partial Length (Start/Stop:P59/I151); Mammalian Expression