Fms (CSFR) (CSF1R)-Autoinhibited Human RTK Kinase KINOMEscan ELECT Binding LeadHunter Assay - US

Background Information:

CSF1R (colony stimulating factor I receptor), formerly known as FMS (McDonough feline sarcoma viral oncogene), is a receptor tyrosine kinase for CSF-1 and expressed primarily in monocytes, macrophages, and human tumor tissue. CSF-1 binding to FMS induces dimerization of the tyrosine kinase domain of the receptor, and stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series.

Family:

Kinase

Sub Family:

RTK

Class:

Protein Tyrosine

Protein Name:

Fms (CSFR)

Uniprot Number:

P07333

Protein Aliases:

CSF-1-R|CSF-1R|M-CSF-R|Proto-oncogene c-Fms|CD antigen CD115

Gene Name:

CSF1R

Gene ID:

1436

Gene Aliases:

C-FMS|CSFR|CD115

Accession Number:

NP_005202.2

Organism:

Human

Construct Details:

Wild Type; Partial Length (Start/Stop: Y538/S939); Mammalian Expression