FGFR2 Human RTK Kinase Enzymatic Radiometric LeadHunter Assay [10 μM ATP] - TW

Background Information:

Fibroblast growth factor (FGF) superfamily consists of 23 members, all of which contain a conserved 120 amino acid (aa) core region that contains six identical, interspersed amino acids. Based on the pI factor, two main groups of FGF are named: acidic FGF (aFGF) and basic FGF (bFGF). The superfamily members act extracellularly through four tyrosine kinase FGF receptors (FGR1 through FGR4), with multiple specificities noted for almost all FGFs. Biological binding of aFGF to its receptors will result in phosphorylation of the receptor and non-receptor proteins and generate its function. FGR2 (FGFR-2, Fibroblast growth factor receptor 2, Keratinocyte growth factor receptor 2, EC 2.7.1.112) is expressed mainly in bone, central nervous system, smooth muscle and tumors. Inhibition of FGR2 may inhibit cranial development and arterial repair as well as facilitate formation and proliferation of some tumors (e.g., prostate, thyroid).

Family:

Kinase

Sub Family:

RTK

Class:

Protein Tyrosine

Protein Name:

FGFR2

Uniprot Number:

P21802

Protein Aliases:

Crouzon syndrome|Pfeiffer syndrome

Gene Name:

FGFR2

Gene ID:

2263

Gene Aliases:

CEK3|TK14|TK25|ECT1|K-SAM|CD332|BEK|KGFR|KSAM

Accession Number:

NM_022976

Organism:

Human

Construct Details:

Fragment (456-770), Recombinant