ERK1 (MAPK3) Human CMGC Kinase Enzymatic Radiometric LeadHunter Assay [10 μM ATP] - TW

Background Information:

ERK1 (extracellular signal-regulated protein kinase) is one of the isoforms of MAP kinase. This 42 kD serine/threonine kinase is activated by dual phosphorylation on tyrosine and threonine residues. Phosphorylation of both residues by the upstream activator MEK is essential not only for ERK1 activation but also for translocation of the ERK1 to the nucleus. Following this activation, ERK1 phosphorylates a large number of regulatory proteins and this directly controls key cellular processes such as transcription, translation and cytoskeletal rearrangement. An inhibitor assay may be of benefit for the treatment of cancer, diabetes, neurodegenerative disorders or asthma.

Family:

Kinase

Sub Family:

CMGC

Class:

Protein Ser/Thr

Protein Name:

ERK1

Uniprot Number:

P27361

Protein Aliases:

MAPK 3|ERT2|Extracellular signal-regulated kinase 1|ERK-1|Insulin-stimulated MAP2 kinase|MAP kinase isoform p44|p44-MAPK|Microtubule-associated protein 2 kinase|p44-ERK1

Gene Name:

MAPK3

Gene ID:

5595

Gene Aliases:

ERK1|p44mapk|p44erk1|PRKM3

Accession Number:

NM_001109891

Organism:

Human

Construct Details:

Full Length, Recombinant