CXCR6 Human Chemokine GPCR Cell Based Antagonist Total Internalization LeadHunter Assay - US

Background Information:

PathHunter Total GPCR Internalization cell lines are engineered to co-express the ProLink™ (PK) tagged GPCR, and an Enzyme Acceptor (EA) tag localized to the endosomes. Activation of the GPCR-PK induces internalization of the receptor in EA-tagged endosomes, forcing complementation of the two β-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal.

Family:

GPCR

Sub Family:

Chemokine

Class:

Class A

Coupling:

Gi/Go

Protein Name:

CXCR6

Uniprot Number:

O00574

Protein Aliases:

CXCR-6|CDw186|G-protein coupled receptor STRL33|G-protein coupled receptor bonzo|CD antigen CD186

Gene Name:

CXCR6

Gene ID:

10663

Gene Aliases:

TYMSTR|STRL33|BONZO|CD186

Accession Number:

AY322543

Organism:

Human

Cell Type:

U2OS