C5aR Human Complement Peptide GPCR Cell Based Antagonist Arrestin LeadHunter Assay - US

Background Information:

PathHunter β-Arrestin GPCR cell lines are engineered to co-express the ProLink™ (PK) tagged GPCR and the Enzyme Acceptor (EA) tagged β-Arrestin. Activation of the GPCR-PK induces β-Arrestin-EA recruitment, forcing complementation of the two β-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal.

Family:

GPCR

Sub Family:

Complement Peptide

Class:

Class A

Coupling:

Gi/Go

Protein Name:

C5aR

Uniprot Number:

P21730

Protein Aliases:

C5a-R|C5aR|CD antigen CD88

Gene Name:

C5AR1

Gene ID:

728

Gene Aliases:

C5A|C5AR|CD88

Accession Number:

NM_001736

Organism:

Human

Cell Type:

CHO-K1