OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
The absorption of orally administered drugs requires the movement of the drug across the intestinal epithelial barrier. Intestinal permeability is a critical characteristic that determines the rate and extent of in vivo absorption and is correlated with the bioavailability of a drug candidate. MDCKII cells are Madin-Darby canine kidney cells which have been widely used as an in vitro model for drug transport and permeability screening of discovery compounds.
Organism:
Dog
Construct Details:
Endogenous
Cell Type:
MDCKII
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Detection Method:
HPLC-MS/MS
Measured Response:
Peak Area Response
Testing Information
Substrate:
Test compound
Incubation:
0 and 40 min at 37°C
Turnaround Time
Standard:
10 Business Days
Additional Information
Brand:
Cerep
Testing Location:
USA - St Charles, MO
RELATED SOLUTIONS
P-gp Substrate Assessment (MDR1-MDCKII) - US
Item: G207
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