ACP1 (LMPTP-B) Human Phosphatase Enzymatic LeadHunter Assay - TW

Background Information:

LMPTP (low molecular weight phosphotyrosine protein phosphatase) is a ubiquitously expressed protein tyrosine phosphatase involved in the modulation of signal transduction by the insulin, platelet derived growth factor (PDGF), and T-cell receptors. The ACP-1 (acid phosphatase ) gene encodes three transcriptional variants (A, B, and C) of LMPTP; the resulting proteins of which are distinct enzyme isoforms with unique chemical properties and activity. Human LMPTP polymorphisms that confer below-normal enzyme activity (i.e. AA or AB allele carriers) are associated with allergic atopic eczema/dermatitis syndrome (AEDS), obesity, diabetes, dyslipidemia and rheumatoid arthritis. Further, total serum IgE levels are lower in carriers of the ACP-1 genotype (CB), which confers above-normal enzyme activity. Over expression of LMPTP enzyme in cells transformed by PTK oncogenes leads to decreased proliferation indicating a possible role in preventing cancer cell proliferation. Therefore, inhibition of LMPTP-B may exacerbate the above noted disease states.

Family:

Phosphatase

Sub Family:

Acid Phosphatase

Class:

Protein Tyrosine

Protein Name:

ACP1

Uniprot Number:

P24666

Protein Aliases:

acid phosphatase of erythrocyte|low molecular weight phosphotyrosine protein phosphatase|red cell acid phosphatase

Gene Name:

ACP1

Gene ID:

52

Gene Aliases:

HAAP|LMW-PTP

Accession Number:

NM_004300

Organism:

Human

Construct Details:

Full Length, Recombinant