ACE Human Angiotensin-Converting Metallo Peptidase Enzymatic LeadHunter Assay - TW

Background Information:

Angiotensin converting enzyme (ACE; kinase II, dipeptidyl carboxypeptidase), a zinc metalloprotease, is responsible for conversion of angiotensin I, generated by activation of the renin-angiotensin system, to angiotensin II; ACE also inactivates bradykinin and other potent vasodilators. Rapid metabolism of angiotensin I to angiotensin II in vivo is primarily due to activity of vascular tissue-bound ACE. Angiotensin II is clearly involved in malignant hypertension or hypertension resulting from stenosis of the renal artery as well as in some patients with normal plasma renin activity. Consequently, inhibitors of ACE are useful as antihypertensive agents; inhibition of bradykinin inactivation may produce dry cough.

Family:

Protease

Sub Family:

Angiotensin-Converting

Class:

Protein (enzyme)

Protein Name:

ACE

Uniprot Number:

P12821

Protein Aliases:

Dipeptidyl carboxypeptidase I

Gene Name:

ACE

Gene ID:

1636

Gene Aliases:

ACE1|CD143

Accession Number:

NM_000789

Organism:

Human

Construct Details:

Fragment (30-1261), Recombinant