OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
The MMP family shares significant sequence homology and a common multidomain structure. On the basis of their preferred substrates, they can be divided into four main classes: collagenases, gelatinases, stromelysins and membrane-type MMPs. These enzymes demonstrate very low activity in normal tissue but are upregulated and/or activated during inflammation and physiological remodeling processes in response to specific stimuli, including cytokines, growth factors and extracellular matrix interactions. Inhibitors may be useful for cancer, rheumatoid arthritis, autoimmune diseases, periodontitis, tissue ulcerlation, atherosclerosis, aneurysm and heart failure.
No. of Assays on Panel:
15
Assays on Panel:
Family
Protease
Name
MMP1 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
114110
Protein
MMP1
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP2 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
114210
Protein
MMP2
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP3 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
114310
Protein
MMP3
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP7 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
114710
Protein
MMP7
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP8 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
114800
Protein
MMP8
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP9 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
114910
Protein
MMP9
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP10 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
114950
Protein
Stromelysin-2
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP12 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
115200
Protein
MMP12
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP13 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
115300
Protein
MMP13
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP14 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
115400
Protein
MMP14
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP15 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
115450
Protein
Matrix metalloproteinase-15
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP17 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
115490
Protein
Matrix metalloproteinase-17
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP19 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
115510
Protein
Matrix metalloproteinase-19
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP20 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
115520
Protein
Matrix metalloproteinase-20
Organism
Human
Assay Sub Type
Enzymatic
Family
Protease
Name
MMP24 Human Matrix Metallopeptidase Enzymatic LeadHunter Assay - TW
Item
115560
Protein
Matrix metalloproteinase-24
Organism
Human
Assay Sub Type
Enzymatic
Testing Information
Test Concentration / Dose:
Suggested concentration for initial testing is 10 µM
Test Sample Requirements:
100 μl of a 10 mM stock or 1 mg pre-weighed powder (assuming FW≦500 and purity 100%)
Turnaround Time
Standard:
10 Business Days
Clinical Relevance
Therapeutic Area:
CNS/Addiction/Pain
Additional Information
Brand:
LeadHunter
Testing Location:
Taiwan - Taipei
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