OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Helicases are key targets in different areas of therapeutic research, and have a critical role in cellular processes such as DNA replication, transcription, recombination, ribosome biogenesis, and repair. Overexpressed in various types of cancer, these enzymes offer a promising target for the development of specific inhibitors. Focusing on helicases can enrich the precision treatment arsenal, reduce adverse effects, and potentially lead to first-in-class therapies. Panel of ATPase Helicase assays that evaluates a molecule’s specificity against DNA or RNA helicases in an off-the-shelf format.
No. of Assays on Panel:
15
Assays on Panel:
Family
Helicase
Name
RECQL5 (RECQ5) Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5753
Protein
RECQ5
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
BRIP1 (FANCJ) Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5755
Protein
FANCJ
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
DHX58 (LGP2) Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5757
Protein
DHX58
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
IFIH1 (MDA5) Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5759
Protein
IFIH1
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
POLQ Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5761
Protein
POLQ
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
RECQL4 (RECQ4) Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5765
Protein
RECQ4
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
RIGI Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5767
Protein
RIG-I
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
DDX3X Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5842
Protein
DDX3X
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
DDX3Y Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5843
Protein
DDX3Y
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
DDX21 Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5844
Protein
DDX21
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
DDX49 Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5846
Protein
DDX49
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
DHX9 Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5847
Protein
DHX9
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
BLM (RECQ2) Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5913
Protein
BLM
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
RECQL (RECQ1) Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5914
Protein
RECQ1
Organism
Human
Assay Sub Type
Enzymatic
Family
Helicase
Name
WRN (RECQ3) Human Helicase ATPase enzymatic LeadHunter Assay - FR
Item
5915
Protein
WRN
Organism
Human
Assay Sub Type
Enzymatic
Family:
Helicase
Class:
ATPase
Organism:
Human
Assay Information
Assay Type:
Biochemical
Assay Sub Type:
Enzymatic
Testing Information
Test Sample Requirements:
Minimum for Screen: 400 μl of 10 mM stock -OR- 2 mg (pMinimum of 130 μl of a 10 mM DMSO stock -OR- 1 mg of pre-weighed solid (assuming FW≦500 and purity 100%) for 10 µM final top concentration
Turnaround Time
Standard:
15 Business Days
Clinical Relevance
Therapeutic Area:
Oncology/Infection Disease/CNS
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
RELATED SOLUTIONS
Helicase Single Dose LeadHunter Panel - FR
Item: P445
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