OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
The receptor for GHS (GHS-R) is a member of the superfamily of G-protein-coupled receptors. Ghrelin, an endogenous 28 amino acid present in the stomach, acts as a specific endogenous ligand for the GHS-R. Ghrelin has demonstrated potent and reproducible GH-releasing activity as well as significant prolactin-, ACTH- and cortisol-releasing activity. Its major physiological function may relate to energy homeostasis.
No. of Assays on Panel:
2
Assays on Panel:
Family
GPCR
Name
GHSR Human Ghrelin GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
1246
Protein
GHSR
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
GHSR Human Ghrelin GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR
Item
1657
Protein
GHSR
Organism
Human
Assay Sub Type
Cell Based
Family:
GPCR
Sub Family:
Ghrelin
Class:
Class A
Protein Name:
GHSR
Uniprot Number:
Q92847
Protein Aliases:
GH-releasing peptide receptor|GHRP|Ghrelin receptor
Gene Name:
GHSR
Gene ID:
2693
Organism:
Human
Cell Type:
CHO-K1
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Agonist & Antagonist
Detection Method:
Fluorimetry
Measured Response:
Fluorescence
Testing Information
Incubation:
22°C
Control Activator:
ghrelin (3 nM)
Test Sample Requirements:
Minimum for 1) Screen: 70 µL of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM finµL testing. 2) Dose Response: 90 µL of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
16
Turnaround Time
Standard:
15 Business Days
Clinical Relevance
Therapeutic Area:
Metabolic Diseases
Adverse / Beneficial Action:
In man, ghrelin was shown to stimulate food intake; it may also increase weight gain by reducing fat utilization.
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
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