CT Human Calcitonin GPCR Cell Based Agonist & Antagonist cAMP LeadHunter Assay - FR

Background Information:

Calcitonin receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin related peptides (CGRPs) and adrenomedullin. Calcitonin receptor agonism is effective in Paget’s disease and some patients with osteoporosis. Agonism may also result in hypocalcemia and hypophosphatemia by direct inhibition of osteoclastic bone resorption.

No. of Assays on Panel:

2

Family:

GPCR

Sub Family:

Calcitonin

Class:

Class B

Protein Name:

CT

Uniprot Number:

P30988

Gene Name:

CALCR

Gene ID:

799

Gene Aliases:

CTR

Organism:

Human

Cell Type:

T-47D