BB2 Human Bombesin GPCR Cell Based Agonist & Antagonist Calcium Flux LeadHunter Assay - FR

Background Information:

Bombesin receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Bombesin receptors are widely distributed in the central nervous system and peripheral tissues. Bombesin BB2 (gastrin-releasing peptide, GRP) receptor agonism may promote gastric emptying, gastrointestinal transit, insulin secretion, inflammation, cell proliferation and tumors. Receptor antagonism may lead to abnormal social behavior.

No. of Assays on Panel:

2

Family:

GPCR

Sub Family:

Bombesin

Class:

Class A

Protein Name:

BB2

Uniprot Number:

P30550

Protein Aliases:

bombesin receptor 2

Gene Name:

GRPR

Gene ID:

2925

Gene Aliases:

BB2|BB2R

Organism:

Human

Cell Type:

HEK293