CysLT2 Human Leukotriene GPCR Cell Based Agonist & Antagonist Calcium Flux LeadHunter Assay - FR

Background Information:

The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. These eicosanoids bind to cysteinyl leukotriene (CysLT) receptors. CysLT receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. CysLT type-2 (CysLT2) receptor is found in lung macrophages, airway smooth muscle, cardiac Purkinje cells, adrenal medulla cells, peripheral blood leukocytes, spleen, placenta, and brain. CysLT2 is less well defined due to a lack of specific agonists and antagonists. Cysteinyl leukotriene antagonists may be therapeutically useful in the treatment of allergic-induced inflammation associated with asthma, rhinitis, pruritis, etc.

No. of Assays on Panel:

2

Family:

GPCR

Sub Family:

Leukotriene

Class:

Class A

Protein Name:

CysLT2

Uniprot Number:

Q9NS75

Protein Aliases:

G-protein coupled receptor GPCR21|hGPCR21|G-protein coupled receptor HG57|HPN321

Gene Name:

CYSLTR2

Gene ID:

57105

Gene Aliases:

CysLT(2)|CYSLT2R|CYSLT2|PSEC0146

Organism:

Human

Cell Type:

HEK293