GABAB (B1/B2) Human GABAB GPCR Cell Based Agonist & Antagonist cAMP LeadHunter Assay - TW

Background Information:

GABA is the major inhibitory transmitter in the mammalian central nervous system. GABAB receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. GABAB receptors are located on pre- and postsynaptic neurons in the central nervous system and peripheral autonomic nerve fibers and sensory fibers. At least two GABAB1 receptor isoforms exist. Functional GABAB receptors are heterodimerized by GABAB1 and GABAB2 subunits. GABAB1a/B2 receptor agonism is useful in the treatment of spasticity and may be anxiolytic, anticonvulsant, muscle relaxation, antihyperalgesic effect, cause sedation and impair motor function. Receptor antagonism may cause convulsions.

No. of Assays on Panel:

2

Family:

GPCR

Sub Family:

GABAB

Class:

Class C

Protein Name:

GABAB (B1/B2)

Uniprot Number:

Q9UBS5

Protein Aliases:

GABA-B receptor

Gene Name:

GABBR1

Gene ID:

2550

Gene Aliases:

hGB1a|GPRC3A

Accession Number:

XM_017007985

Organism:

Human

Construct Details:

Full Length, Recombinant

Cell Type:

CHO-K1