ERRbeta Human Estrogen-Related NHR Functional Antagonist Coactivator LeadHunter Assay - TW

Background Information:

The estrogen-related receptors ERRα, ERRβ, and ERRγ form a subfamily of orphan nuclear receptors that share significant homology with the estrogen receptors ERα and ERβ to possess the potential to positively and negatively regulate estrogen responsiveness. The ER agonist diethylstilbestrol (DES) and the selective ER modulator (SERM) 4-hydroxytamoxifen (4-OHT) have been identified as ERR antagonists. The rational development of synthetic ligands on ERR targets may be useful in improving the treatment of menopause, metabolic disorders, osteoporosis, serum lipids, breast and other cancers.

Family:

NHR

Sub Family:

Estrogen-Related

Class:

Non-Steroid

Protein Name:

ERRbeta

Uniprot Number:

O95718

Gene Name:

ESRRB

Gene ID:

2103

Gene Aliases:

ERR2|ERRbeta|NR3B2|ERRb

Accession Number:

XM_011536547

Organism:

Human

Construct Details:

LBD, Recombinant