B2 Human Bradykinin GPCR Cell Based Antagonist IP1 LeadHunter Assay - TW

Background Information:

Bradykinin receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Bradykinin receptors are found in most peripheral tissues and within the central nervous system. Bradykinin B2 receptor agonism may promote algesia, cough, bronchoconstriction, inflammation and vasodilation. Bradykinin B2 receptor antagonism may find therapeutic use in the treatment of chronic pain and inflammation.

Family:

GPCR

Sub Family:

Bradykinin

Class:

Class A

Protein Name:

B2

Uniprot Number:

P30411

Protein Aliases:

BK-2 receptor

Gene Name:

BDKRB2

Gene ID:

624

Gene Aliases:

BK-2|BKR2

Accession Number:

NM_000623

Organism:

Human

Construct Details:

Full Length, Recombinant

Cell Type:

Chem-1