beta3 Human Adrenoceptor GPCR Cell Based Agonist cAMP LeadHunter Assay - TW

Background Information:

There are three known subtypes of b-adrenergic receptors, b1, b2, and b3, all of which are thought to couple primarily via Gsa to adenylyl cylase, leading to an increase in cAMP. The receptor subtypes differ primarily in their location: b1-adrenoceptors predominate in the heart, cerebral cortex, and the kidney. The major subtype in the lungs, cerebellum, uterus, skeletal muscle, and blood vessels is the b2-adrenoceptor. The b3-adrenoceptor has been detected in brain, stomach, and gall bladder but are expressed predominantly in white and brown adipose tissue (WAT and BAT, respectively) and selective agonists may be potentially useful as anti-obesity drugs.

Family:

GPCR

Sub Family:

Adrenoceptor

Class:

Class A

Protein Name:

beta3

Uniprot Number:

P13945

Protein Aliases:

Beta-3 adrenoceptor

Gene Name:

ADRB3

Gene ID:

155

Accession Number:

NM_000025

Organism:

Human

Construct Details:

Full Length, Recombinant

Cell Type:

HEK293