S1P3 Human Lysophospholipid (S1P) GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR

Item: 2145

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OVERVIEW

DOCUMENTS/REFERENCES

Biological Information

Family:

GPCR

Sub Family:

Lysophospholipid (S1P)

Class:

Class A

Protein Name:

S1P3

Uniprot Number:

Q99500

Protein Aliases:

EDG3|Endothelial differentiation G-protein coupled receptor 3|Lysophospholipid receptor B3|Sphingosine 1-phosphate receptor Edg-3|S1P receptor Edg-3

Gene Name:

S1PR3

Gene ID:

1903

Gene Aliases:

EDG-3

Accession Number:

NM_005226

Organism:

Human

Construct Details:

Recombinant

Cell Type:

CHO-K1

Assay Information

Assay Type:

Functional

Assay Sub Type:

Cell Based

Functional Mode:

Antagonist

Detection Method:

Fluorimetry

Measured Response:

Fluorescence

Testing Information

Incubation:

Control Activator:

Sphingosine 1-phosphate (S1P) (10 nM)

Test Concentration / Dose:

Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.

Test Sample Requirements:

Minimum for 1) Screen: 70 µL of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM finµL testing. 2) Dose Response: 90 µL of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.

Minimum Order Quantity:

Turnaround Time

Standard:

15 Business Days

Clinical Relevance

Therapeutic Area:

Inflammation/Allergy

Additional Information

Brand:

LeadHunter

Testing Location:

France - Celle L'Evescault