OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Neurotensin (NT) receptors belong to the superfamily of G protein-coupled receptors. Neurotensin NT1 an NT2 receptors have seven transmembrane domains, whereas NT3 has a single transmembrane domain. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Neurotensin NT receptors are widely distributed in the central nervous system and gastrointestinal tract.
Family:
GPCR
Sub Family:
Neurotensin
Class:
Class A
Protein Name:
NT1
Uniprot Number:
P30989
Protein Aliases:
NTR1|High-affinity levocabastine-insensitive neurotensin receptor|NTRH
Gene Name:
NTSR1
Gene ID:
4923
Gene Aliases:
NTR|NTRR
Accession Number:
XM_011528827
Organism:
Human
Construct Details:
Recombinant
Cell Type:
CHO-K1
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Antagonist
Detection Method:
Fluorimetry
Measured Response:
Fluorescence
Testing Information
Incubation:
RT
Control Inhibitor:
SR142948A
Control Activator:
neurotensin (0.3 nM)
Test Concentration / Dose:
Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.
Test Sample Requirements:
Minimum for 1) Screen: 70 µL of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM finµL testing. 2) Dose Response: 90 µL of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
16
Turnaround Time
Standard:
15 Business Days
Reference Compound Data
Clinical Relevance
Therapeutic Area:
CNS/Addiction/Pain
Adverse / Beneficial Action:
Neurotensin NT1 receptor agonism may be useful in the treatment of schizophrenia, may increase gastric emptying and colonic propulsion as well as cardiac stimulation, cell proliferation and mast cell secretion.
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
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