BLT1 (LTB4) Human Leukotriene GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR

Background Information:

Leukotriene (LT) receptors most sensitive to the endogenous ligand BLT4 are named BLT receptors, whereas those preferentially activated by the CysLTs are named LTC4, D4 and E4. LT receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. LTB4 receptors are found in leukocytes, spleen and thymus and also reported to be present in peritoneal macrophages and eosinophils.

Family:

GPCR

Sub Family:

Leukotriene

Class:

Class A

Protein Name:

BLT1 (LTB4)

Uniprot Number:

Q15722

Protein Aliases:

LTB4-R1|Chemoattractant receptor-like 1|G-protein coupled receptor 16|P2Y purinoceptor 7|P2Y7

Gene Name:

LTB4R

Gene ID:

1241

Gene Aliases:

BLT|BLT1|BLTR|CMKRL1|GPR16|P2RY7

Accession Number:

NM_181657

Organism:

Human

Construct Details:

Recombinant

Cell Type:

CHO-K1